Abstract
Amphotericin B(AmB) formulations, Fungizone, and Amphotec caused substantially greater proinflammatory cytokine release than AmBisome (L-AMB) and Abelcet in TPA differentiated THP-1 macrophages as determined by antibody based protein arrays. Lipopolysaccharide but not AmB induced significant pro-inflammatory cytokines in human endothelial cells.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Amphotericin B / chemistry
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Amphotericin B / pharmacology*
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Cell Line, Tumor
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Cells, Cultured
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Chemistry, Pharmaceutical
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Cytokines / antagonists & inhibitors
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Cytokines / biosynthesis
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Cytokines / metabolism*
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Endothelium, Vascular / cytology*
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Endothelium, Vascular / drug effects*
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Endothelium, Vascular / metabolism
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Humans
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Macrophages / drug effects*
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Macrophages / metabolism
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Monocytes / drug effects
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Monocytes / metabolism