Synthesis of novel N-substituted imidazolecarboxylic acid hydrazides as monoamine oxidase inhibitors

Farmaco. 2005 Mar;60(3):237-40. doi: 10.1016/j.farmac.2004.12.007.

Abstract

Novel 2-alkylsulfanyl-1-benzyl-5-imidazolecarboxylic acid hydrazides (15a,b) were synthesized as analogues of isocarboxazide, which is a known nonselective irreversible monoamine oxidase inhibitor and tested for monoamine oxidase A and B inhibitory activity. Neither of the compounds showed any inhibition of MAO B activity up to a high concentration of 100 microM. An MAO A activity was only slowly inhibited at this high concentration after prolonged incubation with either compound. This suggests any observed inhibition is not very specific.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Hydrazines / chemical synthesis*
  • Hydrazines / pharmacology
  • Imidazoles / chemical synthesis*
  • Imidazoles / pharmacology
  • Isocarboxazid / chemistry
  • Monoamine Oxidase / metabolism*
  • Monoamine Oxidase Inhibitors / chemical synthesis*
  • Monoamine Oxidase Inhibitors / pharmacology
  • Structure-Activity Relationship

Substances

  • Hydrazines
  • Imidazoles
  • Monoamine Oxidase Inhibitors
  • Isocarboxazid
  • Monoamine Oxidase