Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction

Angew Chem Int Ed Engl. 2005 Apr 29;44(18):2704-2707. doi: 10.1002/anie.200462316.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Biomimetic Materials / chemical synthesis*
  • Biomimetic Materials / chemistry
  • Biomimetic Materials / metabolism
  • Biomimetic Materials / pharmacology*
  • Crystallography, X-Ray
  • Humans
  • Models, Molecular
  • Nuclear Magnetic Resonance, Biomolecular
  • Protein Binding / drug effects
  • Protein Structure, Quaternary
  • Proto-Oncogene Proteins c-mdm2 / antagonists & inhibitors
  • Proto-Oncogene Proteins c-mdm2 / metabolism*
  • Terphenyl Compounds / chemical synthesis
  • Terphenyl Compounds / chemistry*
  • Terphenyl Compounds / metabolism
  • Terphenyl Compounds / pharmacology*
  • Tumor Suppressor Protein p53 / antagonists & inhibitors
  • Tumor Suppressor Protein p53 / metabolism*

Substances

  • Terphenyl Compounds
  • Tumor Suppressor Protein p53
  • MDM2 protein, human
  • Proto-Oncogene Proteins c-mdm2