Internet-2 is an advanced computer network, which has been widely used for medical imaging applications such as teleradiology and teleconsultation, since Internet-2 can fulfill the requirements for high-speed data transmission and short turn-around time with low operation cost once installed. However, such high performance of Internet-2 may not be retained for global access from international network peers. Considering the international Internet-2 connection between the PolyU and the IPI/USC, there exist two major factors, network looping in the US and bottleneck of the connection, raising the round-trip time and limiting the available bandwidth, respectively. The available bandwidth will be further underutilized if the TCP/IP parameters at the sending and receiving computers are not appropriately chosen. This paper proposes a repeatable and consistent protocol to automatically tune these parameters for the clinical applications.