Distribution of CCR5-delta32, CCR2-64I, and SDF1-3'A mutations in populations from the Brazilian Amazon region

Hum Biol. 2004 Aug;76(4):643-6. doi: 10.1353/hub.2004.0052.

Abstract

The frequency distribution of the CCR5-delta32, CCR2-64I, and SDF1-3'A alleles was studied in the urban population of Belém and in Afro-Brazilians, Amerindians, and Japanese immigrants in the state of Pará, Brazil. The results suggest that Amerindians may be genetically more susceptible to HIV-1 infection and disease progression than the other human groups studied.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asian People / genetics
  • Black People / genetics
  • Brazil
  • Chemokines / genetics
  • Disease Progression
  • Gene Frequency*
  • Genetic Predisposition to Disease / ethnology*
  • Genetics, Population*
  • Genotype
  • HIV-1 / genetics
  • Humans
  • Indians, South American / genetics
  • Japan / ethnology
  • Mutation
  • Polymorphism, Restriction Fragment Length*
  • Receptors, CCR5 / genetics*

Substances

  • Chemokines
  • Receptors, CCR5