Novel bromotyrosine derivatives that inhibit growth of the fish pathogenic bacterium Aeromonas hydrophila, from a marine sponge Hexadella sp

J Org Chem. 2005 Mar 4;70(5):1893-6. doi: 10.1021/jo048203j.

Abstract

Three new bromotyrosine derivatives, 11-N-methylmoloka'iamine (1), 11-N-cyano-11-N-methylmoloka'iamine (2), and kuchinoenamine (3), were isolated as antibacterial constituents from a marine sponge Hexadella sp. Their structures were elucidated on the basis of spectral and chemical methods. They exhibited moderate antibacterial activity against the fish pathogenic bacterium Aeromonas hydrophila.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aeromonas hydrophila* / drug effects
  • Aeromonas hydrophila* / growth & development
  • Aeromonas hydrophila* / pathogenicity
  • Animals
  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology*
  • Bridged-Ring Compounds / chemistry*
  • Bridged-Ring Compounds / isolation & purification
  • Bridged-Ring Compounds / pharmacology*
  • Microbial Sensitivity Tests
  • Models, Chemical
  • Models, Molecular
  • Molecular Conformation
  • Nitriles / chemistry*
  • Nitriles / isolation & purification
  • Nitriles / pharmacology*
  • Porifera / chemistry*
  • Tyrosine / analogs & derivatives*
  • Tyrosine / chemistry*
  • Tyrosine / isolation & purification
  • Tyrosine / pharmacology*

Substances

  • 11-N-cyano-11-N-methylmolokaiamine
  • 11-N-methylmolokaiamine
  • Anti-Bacterial Agents
  • Bridged-Ring Compounds
  • Nitriles
  • bromotyrosine
  • kuchinoenamine
  • Tyrosine