Abstract
A strain of Streptomyces nodosus (NPS007994) isolated from a marine sediment collected in Scripps Canyon, La Jolla, California, was found to produce lajollamycin (1), a nitro-tetraene spiro-beta-lactone-gamma-lactam antibiotic. The structure was established by complete analysis of spectroscopic data and comparison with known antibiotics oxazolomycin (2), 16-methyloxazolomycin (3), and triedimycin B (4). Lajollamycin (1) showed antimicrobial activity against both drug-sensitive and -resistant Gram-positive bacteria and inhibited the growth of B16-F10 tumor cells in vitro.
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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California
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Gram-Positive Bacteria / drug effects
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Lactams / chemistry
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Lactams / isolation & purification*
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Lactams / pharmacology
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Mice
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Microbial Sensitivity Tests
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Molecular Structure
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Oxazoles / chemistry
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Polyunsaturated Alkamides
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Spiro Compounds / chemistry
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Spiro Compounds / isolation & purification*
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Spiro Compounds / pharmacology
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Streptomyces / chemistry*
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents
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Lactams
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Oxazoles
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Polyunsaturated Alkamides
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Spiro Compounds
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lajollamycin
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curromycin B