Abstract
Frontotemporal dementia (FTD) often coexists with motor neuron disease (MND). To characterize glucose hypometabolism in patients with FTD with MND (FTD/MND), the authors compared the glucose metabolism of 8 patients with FTD/MND with that of 29 patients with FTD. All of the patients with FTD/MND showed glucose hypometabolism only in the frontal area, whereas most patients with FTD had hypometabolism in the frontal and temporal areas. FTD/MND also showed a more symmetric pattern of glucose hypometabolism than FTD.
MeSH terms
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Aged
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Bulbar Palsy, Progressive / complications
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Bulbar Palsy, Progressive / diagnostic imaging
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Bulbar Palsy, Progressive / metabolism
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Cerebellum / diagnostic imaging
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Cerebellum / metabolism*
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Cerebral Cortex / diagnostic imaging
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Cerebral Cortex / metabolism
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Dementia / complications
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Dementia / diagnostic imaging
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Dementia / metabolism*
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Dominance, Cerebral
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Female
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Fluorodeoxyglucose F18* / pharmacokinetics
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Glucose / metabolism*
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Humans
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Male
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Middle Aged
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Motor Neuron Disease / complications
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Motor Neuron Disease / metabolism*
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Organ Specificity
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Positron-Emission Tomography*
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Radiopharmaceuticals* / pharmacokinetics
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Temporal Lobe / diagnostic imaging
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Temporal Lobe / metabolism*
Substances
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Radiopharmaceuticals
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Fluorodeoxyglucose F18
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Glucose