Allergic contact dermatitis from cocamidopropyl betaine, cocamidoamine, 3-(dimethylamino)propylamine, and oleamidopropyl dimethylamine: co-reactions or cross-reactions?

Dermatitis. 2004 Sep;15(3):146-9. doi: 10.2310/6620.2004.04011.

Abstract

We present the case of a patient with facial dermatitis caused by sensitization to cocamidopropyl betaine. The patient also had positive patch-test reactions to cocamidoamine, 3-(dimethylamino)propylamine, and oleamidopropyl dimethylamine. The presence of 3-(dimethylamino)propylamine as an impurity in all of these substances can be hypothesized to explain these simultaneous reactions.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Allergens / adverse effects
  • Betaine / adverse effects*
  • Betaine / analogs & derivatives*
  • Cosmetics / adverse effects*
  • Cross Reactions
  • Dermatitis, Allergic Contact / etiology*
  • Diamines / adverse effects*
  • Drug Synergism
  • Female
  • Hair Preparations / adverse effects*
  • Humans
  • Propylamines / adverse effects*
  • Surface-Active Agents / adverse effects*

Substances

  • Allergens
  • Cosmetics
  • Diamines
  • Hair Preparations
  • Propylamines
  • Surface-Active Agents
  • N-(3-(dimethylamino)propyl)oleamide
  • Betaine
  • cocamidopropyl betaine
  • 3-dimethylaminopropylamine