Abstract
The present study showed the association of a severe acute respiratory syndrome coronavirus (SCoV) accessory protein, 3a, with plasma membrane and intracellular SCoV particles in infected cells. 3a protein appeared to undergo posttranslational modifications in infected cells and was incorporated into SCoV particles, establishing that 3a protein was a SCoV structural protein.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Caco-2 Cells
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Chlorocebus aethiops
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Humans
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Microscopy, Immunoelectron
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Protein Processing, Post-Translational
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Severe acute respiratory syndrome-related coronavirus / genetics
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Severe acute respiratory syndrome-related coronavirus / physiology*
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Severe acute respiratory syndrome-related coronavirus / ultrastructure
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Vero Cells
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Viral Envelope Proteins
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Viral Proteins / genetics
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Viral Proteins / isolation & purification
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Viral Proteins / physiology*
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Viral Structural Proteins / genetics
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Viral Structural Proteins / isolation & purification
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Viral Structural Proteins / physiology*
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Viroporin Proteins
Substances
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3a protein, SARS-CoV
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Viral Envelope Proteins
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Viral Proteins
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Viral Structural Proteins
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Viroporin Proteins