apoE isoforms and measures of anxiety in probable AD patients and Apoe-/- mice

Neurobiol Aging. 2005 May;26(5):637-43. doi: 10.1016/j.neurobiolaging.2004.06.003.

Abstract

Increased anxiety may occur in up to 70% of AD patients during the course of their illness. Here we show that human apoE isoforms, which differ in AD risk, have differential effects on measures of anxiety in adult Apoe-/- male mice expressing human apoE3 or apoE4 in their brains and male probable AD (PRAD) patients. Compared with wild-type mice, Apoe-/- mice without human apoE or with apoE4, but not apoE3, showed increased measures of anxiety. These behavioral alterations were associated with reduced microtubule-associated protein 2-positive neuronal dendrites in the central nucleus of the amygdala. Consistent with the mouse data, male and female PRAD patients with epsilon4/epsilon4 showed higher anxiety scores than those with epsilon3/epsilon3. We conclude that human apoE isoforms have differential effects on measures of anxiety.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / genetics
  • Alzheimer Disease / metabolism*
  • Alzheimer Disease / physiopathology
  • Analysis of Variance
  • Animals
  • Anxiety / etiology
  • Anxiety / metabolism*
  • Apolipoproteins E / deficiency*
  • Apolipoproteins E / genetics
  • Apolipoproteins E / metabolism
  • Behavior, Animal
  • Female
  • Glucocorticoids / cerebrospinal fluid
  • Humans
  • Hydrocortisone / cerebrospinal fluid
  • Immunohistochemistry / methods
  • Male
  • Maze Learning / physiology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Middle Aged
  • Protein Isoforms / metabolism*
  • Reflex, Acoustic / genetics
  • Sex Factors
  • Sleep Apnea, Central / complications

Substances

  • Apolipoproteins E
  • Glucocorticoids
  • Protein Isoforms
  • Hydrocortisone