Abstract
Matrical differentiation in basal cell carcinoma (BCC) is rare. Only nine cases have been described that showed typical diagnostic features of BCC, in addition to shadow cells indicating hair-matrix differentiation. These cases often present a diagnostic challenge due to confusion with pilomatrixoma or pilomatrix carcinoma. We present a case of BCC with matrical differentiation in a 78-year-old man. Immunohistochemical and molecular methods are used to differentiate this lesion from benign or malignant forms of pilomatrixoma. differentiation: a case study with analysis of beta-catenin.
Publication types
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Case Reports
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aged
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Biomarkers, Tumor / analysis
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Carcinoma, Basal Cell / chemistry
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Carcinoma, Basal Cell / pathology*
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Carcinoma, Basal Cell / surgery
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Cell Transformation, Neoplastic*
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Cytoskeletal Proteins / analysis*
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Diagnosis, Differential
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Hair Diseases / diagnosis
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Humans
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Immunohistochemistry
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Male
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Mohs Surgery
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Pilomatrixoma / diagnosis
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Skin Neoplasms / chemistry
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Skin Neoplasms / pathology*
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Skin Neoplasms / surgery
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Trans-Activators / analysis*
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beta Catenin
Substances
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Biomarkers, Tumor
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CTNNB1 protein, human
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Cytoskeletal Proteins
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Trans-Activators
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beta Catenin