Results of endo-surgical treatment in 81 patients with choledocholithiasis are analyzed. There were 60 women and 21 men aged from 24 to 77 years. It is demonstrated that inclusion of octreotid and dicetel in combined two-stage treatment of choledocholithiasis decreases the risk of pancreatitis and bleeding after endoscopic papillosphincterotomy, number of postoperative complications, hospital stay, cost of treatment and provides good cosmetic effect.