Differential immune induction with subcutaneous versus oral administration of a diabetogenic insulin peptide in the NOD mouse

Ann N Y Acad Sci. 2004 Dec:1029:328-30. doi: 10.1196/annals.1309.039.

Abstract

The B chain insulin peptide 9 to 23 (B:9-23) is a dominant T cell epitope of the NOD mouse. Given in oral form with multiple different vehicles, it did not alter expression of insulin autoantibodies in contrast to subcutaneous administration.

Publication types

  • Comparative Study

MeSH terms

  • Administration, Oral
  • Animals
  • Autoantibodies / blood*
  • Diabetes Mellitus, Type 1 / immunology*
  • Immunity, Mucosal*
  • Injections, Subcutaneous
  • Insulin / administration & dosage*
  • Insulin / immunology
  • Mice
  • Mice, Inbred NOD
  • Peptide Fragments / administration & dosage*
  • Peptide Fragments / immunology
  • T-Lymphocytes / immunology

Substances

  • Autoantibodies
  • Insulin
  • Peptide Fragments
  • insulin B (9-23)