Cubic phases and cubic phase dispersions in a phospholipid-based system

Markus Johnsson; Justas Barauskas; Fredrik Tiberg

doi:10.1021/ja043331a

Cubic phases and cubic phase dispersions in a phospholipid-based system

J Am Chem Soc. 2005 Feb 2;127(4):1076-7. doi: 10.1021/ja043331a.

Authors

Markus Johnsson¹, Justas Barauskas, Fredrik Tiberg

Affiliation

¹ Camurus AB, Ideon, Gamma 2, Sölvegatan 41, SE-223 70, Lund, Sweden, and Physical Chemistry 1, Center for Chemistry and Chemical Engineering, Lund University, PO Box 124, SE-221 00 Lund, Sweden. markus.johnsson@camurus.ideon.se

PMID: 15669827
DOI: 10.1021/ja043331a

Abstract

A cubic liquid crystalline phase forming system based on the phospholipid dioleoylphosphatidylethanolamine (DOPE) which is fortified with small amounts of PEGylated (poly(ethylene) glycol) glycerol monooleate (PEG(660)-GMO) is characterized. The cubic phase formed by the DOPE/PEG(660)-GMO/water system coexists with water in the dilute part of the phase diagram and can be fragmented into colloidal size particles with retained cubic phase structure.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Microscopy, Electron, Transmission
Phosphatidylethanolamines / chemistry
Phospholipids / chemistry*
Polyethylene Glycols / chemistry
X-Ray Diffraction

Substances

1,2-dioleoyl-glycero-3-phosphatidyl ethanolamine
Phosphatidylethanolamines
Phospholipids
Polyethylene Glycols