The HLA locus and multiple sclerosis in Sicily

Neurology. 2005 Jan 25;64(2):361-3. doi: 10.1212/01.WNL.0000149765.71212.0A.

Abstract

The authors report the analysis of HLA-class II allelic heterogeneity in a well characterized multiple sclerosis (MS) Sicilian dataset. Family-based association analysis revealed evidence for excess transmission to affected individuals for alleles HLA-DRB1*1501, DRB1*04, and DQB1*0302. When analyzed as haplotypes, the authors observed excess transmission for the DRB1*0400-DQB1*0302 haplotype. Sicilian patients share the HLA-DRB1*1501 susceptibility allele with affected living in continental Italy, but also display the allelic heterogeneity that characterizes Mediterranean populations.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Age of Onset
  • Alleles
  • Cohort Studies
  • Disability Evaluation
  • Female
  • Gene Frequency
  • Gene Pool
  • Genes, MHC Class II*
  • Genetic Predisposition to Disease
  • HLA-D Antigens / genetics*
  • Haplotypes / genetics
  • Humans
  • Incidence
  • Linkage Disequilibrium
  • Male
  • Multiple Sclerosis / epidemiology*
  • Multiple Sclerosis / genetics
  • Prevalence
  • Risk
  • Severity of Illness Index
  • Sicily / epidemiology

Substances

  • HLA-D Antigens