Abstract
New pyrrolo[1,2-a]quinoxaline-2- or -4-carboxylic acid hydrazide derivatives were synthesized from nitroaniline or 1,2-phenylenediamine, and evaluated in vitro for their antimycobacterial activity as part of a TAACF TB screening program. Two compounds 7c and 13 showed an interesting activity at 6.25 microg/mL against Mycobacterium tuberculosis H37Rv, with a 94 and 100 percentage inhibition, respectively.
MeSH terms
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Animals
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Antitubercular Agents / chemical synthesis
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Antitubercular Agents / chemistry
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Antitubercular Agents / pharmacokinetics
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Carboxylic Acids / chemistry*
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Chlorocebus aethiops
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Crystallography, X-Ray
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Drug Evaluation, Preclinical
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Hydrazines / chemical synthesis*
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Hydrazines / chemistry
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Hydrazines / pharmacology*
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In Vitro Techniques
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Models, Molecular
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Molecular Structure
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Mycobacterium tuberculosis / drug effects*
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Quinoxalines / chemistry*
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Stereoisomerism
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Structure-Activity Relationship
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Vero Cells
Substances
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Anti-Bacterial Agents
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Antitubercular Agents
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Carboxylic Acids
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Hydrazines
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Quinoxalines