Opioid receptors and heart resistance to arrhythmogenic factors

Bull Exp Biol Med. 2004 Aug;138(2):107-12. doi: 10.1023/b:bebm.0000048363.84047.10.

Abstract

We present detailed data on the role of central and peripheral opioid receptors in the regulation of heart resistance to arrhythmogenic factors. Stimulation of peripheral delta2- and kappa1-receptors increases heart resistance to the arrhythmogenic effect of acute ischemia and reperfusion. Activation of peripheral mu- and delta1-opioid receptors improves electrical stability of the heart in animals with postinfarction cardiosclerosis. Possible mechanisms for opioidergic regulation of heart resistance to arrhythmogenic factors are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aconitine / pharmacology
  • Animals
  • Arrhythmias, Cardiac / drug therapy
  • Arrhythmias, Cardiac / etiology*
  • Arrhythmias, Cardiac / prevention & control
  • Calcium Chloride / pharmacology
  • Catecholamines / pharmacology
  • Heart / drug effects*
  • Myocardial Reperfusion Injury / prevention & control
  • Opioid Peptides / physiology
  • Rats
  • Receptors, Opioid / physiology*

Substances

  • Catecholamines
  • Opioid Peptides
  • Receptors, Opioid
  • Calcium Chloride
  • Aconitine