Despite the availability of factual information about breast cancer, there continues to be an abundance of misperceptions about the disease. This study, guided by the Patient/Provider/System Model for cancer screening, describes perceptions about breast cancer among African American women (N = 179) at primary care centers. Data were collected using the Breast Cancer Perceptions and Knowledge Survey and a demographic questionnaire. Breast cancer pamphlets available at the centers were evaluated (readability, extent they challenged misperceptions). The average age of the women was 34 years with an average educational level of 12 years. A number of misperceptions were prevalent. The majority viewed breast self-examination as a form of early detection and some viewed pain as an indicator of cancer. Pamphlets did not explicitly challenge the misperceptions and the SMOG reading level was high. Intervention studies are needed to identify the effective methods to challenge and correct misperceptions about breast cancer for these women.