Abstract
BRCA1 is one of the most important breast cancer susceptibility genes. It plays key roles in DNA damage repair, cell cycle checkpoint regulation, gene transcription chromatin stability, and cell proliferation. In this paper, advance in basic researches on BRCA1 is reviewed, and the role of BRCA1 in cancer development and progression is discussed, that may facilitate potential clinical application of BRCA1.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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BRCA1 Protein / chemistry
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BRCA1 Protein / genetics*
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BRCA1 Protein / metabolism
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BRCA1 Protein / physiology
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Breast Neoplasms / genetics*
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Breast Neoplasms / metabolism
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Breast Neoplasms / pathology
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Cell Cycle
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Cell Proliferation
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Chromatin Assembly and Disassembly*
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DNA Repair*
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Female
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Genetic Predisposition to Disease
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Humans
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Transcription, Genetic