Surgical mediastinal staging in daily practice

Lung Cancer. 2005 Feb;47(2):243-51. doi: 10.1016/j.lungcan.2004.06.017.

Abstract

Study objectives: An adequately staged mediastinum remains obligatory in patients with NSCLC prior to surgery. In this study, we investigated the accuracy of preoperative surgical mediastinal staging procedures in four hospitals.

Setting: Non-university teaching hospital and three surrounding community hospitals in Eindhoven, The Netherlands.

Patients, measurements and results: Patients with NSCLC who underwent mediastinoscopy and/or thoracotomy, between 1993 and 1999. Adherence to guidelines for indicating and performing mediastinoscopy were investigated and compared in four hospitals. Guidelines for indicating mediastinoscopy were adequately followed in two-thirds of cases. Mediastinoscopy was performed according to gold standards in 40% of cases. The hospital with the smallest number of evaluated patients scored the worst. Postoperatively, 17% of patients appeared to have "unforeseen N2-3 disease". In approximately 18% of these "upstaged" patients, thoracotomy could have been prevented, if guidelines had been followed adequately.

Conclusions: In clinical practice the adherence to staging guidelines with respect to mediastinoscopy is insufficient in one-third of patients. Furthermore, mediastinoscopy was performed according to gold standards in 40% of patients.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Non-Small-Cell Lung / pathology*
  • Carcinoma, Non-Small-Cell Lung / surgery
  • Female
  • Hospitals, Teaching / standards*
  • Hospitals, Teaching / statistics & numerical data
  • Humans
  • Lung Neoplasms / pathology*
  • Lung Neoplasms / surgery
  • Male
  • Mediastinal Neoplasms / pathology*
  • Mediastinoscopy
  • Middle Aged
  • Neoplasm Staging / methods*
  • Reproducibility of Results
  • Retrospective Studies
  • Sensitivity and Specificity
  • Thoracotomy