Palladium-catalyzed enantioselective diboration of prochiral allenes

J Am Chem Soc. 2004 Dec 22;126(50):16328-9. doi: 10.1021/ja044167u.

Abstract

Pd-catalyzed diboration of prochiral allenes occurs exclusively at the internal position and is remarkably accelerated in the presence of Lewis basic ligand structures. On the basis of preliminary observations, a chiral ligand was employed, and the enantiomeric excess of a variety of diboration products was found to be in the range of 86-92% ee. The chiral diboron reaction products should be useful in organic synthesis, and preliminary experiments suggest that they may participate in allylation reactions with a high level of chirality transfer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alkadienes / chemistry*
  • Boron Compounds / chemical synthesis*
  • Boron Compounds / chemistry
  • Catalysis
  • Organophosphorus Compounds / chemistry
  • Palladium / chemistry
  • Stereoisomerism

Substances

  • Alkadienes
  • Boron Compounds
  • Organophosphorus Compounds
  • phosphoramidite
  • propadiene
  • Palladium