Altered apoptosis and cell cycling of mast cells in bone marrow lesions of patients with systemic mastocytosis

Haematologica. 2004 Dec;89(12):1525-7.

Abstract

Enhanced expression of the apoptosis-preventing protein bcl-xL and the cell cycle-regulating protein p21 was observed in bone marrow infiltrates of systemic mastocytosis. Expression of bcl-2, Ki67, and p53 as well as ISEL apoptosis staining were comparable in patients with mastocytosis and in controls. An altered rate of apoptosis and cell cycling may contribute to accumulation of mast cells in mastocytosis.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Apoptosis*
  • Bone Marrow / pathology*
  • Cell Cycle
  • Cyclin-Dependent Kinase Inhibitor p21 / analysis
  • Female
  • Humans
  • In Situ Nick-End Labeling
  • Ki-67 Antigen / analysis
  • Male
  • Mast Cells / chemistry
  • Mast Cells / pathology*
  • Mastocytosis, Systemic / pathology*
  • Middle Aged
  • Proto-Oncogene Proteins c-bcl-2 / analysis
  • Tumor Suppressor Protein p53 / analysis

Substances

  • CDKN1A protein, human
  • Cyclin-Dependent Kinase Inhibitor p21
  • Ki-67 Antigen
  • Proto-Oncogene Proteins c-bcl-2
  • Tumor Suppressor Protein p53