Abstract
The isolation and structure elucidation of 1 from the Basidomycete fungus Baeospora myosura is described. This new ene-triyne antibiotic was most potent against Gram-positive bacteria, while it was less active against Gram-negative bacteria and a yeast. MICs against several strains of Staphylococcus aureus were as low as 0.001 microg/mL. Analogues of 1 that did not contain the ene-triyne moiety were inactive against all microorganisms tested. The isolation of this new natural product was complicated by the highly reactive nature of the conjugated terminal polyacetylene.
MeSH terms
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Acetylene / analogs & derivatives*
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Acetylene / chemistry
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Acetylene / isolation & purification*
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Acetylene / pharmacology
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Basidiomycota / chemistry*
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Candida albicans / drug effects
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Microbial Sensitivity Tests
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Nuclear Magnetic Resonance, Biomolecular
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Oxidation-Reduction
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Polymers / chemistry
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Polymers / isolation & purification*
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Polymers / pharmacology
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Polyynes
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Staphylococcus aureus / drug effects
Substances
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Anti-Bacterial Agents
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Polymers
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Polyynes
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Acetylene