A new ene-triyne antibiotic from the fungus Baeospora myosura

J Nat Prod. 2004 Nov;67(11):1900-2. doi: 10.1021/np0497853.

Abstract

The isolation and structure elucidation of 1 from the Basidomycete fungus Baeospora myosura is described. This new ene-triyne antibiotic was most potent against Gram-positive bacteria, while it was less active against Gram-negative bacteria and a yeast. MICs against several strains of Staphylococcus aureus were as low as 0.001 microg/mL. Analogues of 1 that did not contain the ene-triyne moiety were inactive against all microorganisms tested. The isolation of this new natural product was complicated by the highly reactive nature of the conjugated terminal polyacetylene.

Publication types

  • Comparative Study

MeSH terms

  • Acetylene / analogs & derivatives*
  • Acetylene / chemistry
  • Acetylene / isolation & purification*
  • Acetylene / pharmacology
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Basidiomycota / chemistry*
  • Candida albicans / drug effects
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Microbial Sensitivity Tests
  • Nuclear Magnetic Resonance, Biomolecular
  • Oxidation-Reduction
  • Polymers / chemistry
  • Polymers / isolation & purification*
  • Polymers / pharmacology
  • Polyynes
  • Staphylococcus aureus / drug effects

Substances

  • Anti-Bacterial Agents
  • Polymers
  • Polyynes
  • Acetylene