Abstract
Antibody-dependent complement killing of Bordetella pertussis after immunization with a three-component acellular pertussis vaccine was characterized. Postimmunization activity was unchanged for about half of the adult vaccine recipients. The responses of the other individuals were complex, with evidence of both beneficial and antagonistic responses occurring, sometimes in the same individual.
Publication types
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Clinical Trial
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Randomized Controlled Trial
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antibodies, Bacterial / blood
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Blood Bactericidal Activity
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Bordetella pertussis / immunology*
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Complement System Proteins / physiology*
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Double-Blind Method
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Humans
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Immunization
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Immunoglobulin A / blood
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Immunoglobulin G / blood
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Pertussis Vaccine / immunology*
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Prospective Studies
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Vaccines, Acellular / immunology
Substances
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Antibodies, Bacterial
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Immunoglobulin A
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Immunoglobulin G
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Pertussis Vaccine
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Vaccines, Acellular
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Complement System Proteins