Abstract
In Candida albicans, calcineurin is essential for virulence and survival during membrane perturbation by azoles. Crz1 is a proposed downstream target of calcineurin based on studies of Saccharomyces cerevisiae. However, the in vitro phenotypes of C. albicans crz1/crz1 and calcineurin mutants differ and Crz1 is not required for virulence.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antifungal Agents / pharmacology*
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Calcineurin / pharmacology*
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Candida albicans / drug effects*
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Candida albicans / pathogenicity*
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Drug Resistance, Fungal
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Fluconazole / pharmacology*
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Mice
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Mice, Inbred ICR
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Tacrolimus / pharmacology
Substances
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Antifungal Agents
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Fluconazole
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Calcineurin
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Tacrolimus