3D brain mapping using a deformable neuroanatomy

Phys Med Biol. 1994 Mar;39(3):609-18. doi: 10.1088/0031-9155/39/3/022.

Abstract

This paper presents two different mathematical methods that can be used separately or in conjunction to accommodate shape variabilities between normal human neuroanatomies. Both methods use a digitized textbook to represent the complex structure of a typical normal neuroanatomy. Probabilistic transformations on the textbook coordinate system are defined to accommodate shape differences between the textbook and images of other normal neuroanatomies. The transformations are constrained to be consistent with the physical properties of deformable elastic solids in the first method and those of viscous fluids in the second. Results presented in this paper demonstrate how a single deformable textbook can be used to accommodate normal shape variability.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Algorithms
  • Animals
  • Brain / pathology*
  • Brain Mapping / methods*
  • Humans
  • Image Processing, Computer-Assisted
  • Imaging, Three-Dimensional / methods*
  • Magnetic Resonance Imaging
  • Models, Statistical
  • Models, Theoretical
  • Neurons / metabolism
  • Neurons / pathology*
  • Time Factors