Effects of a novel anti-hyperlipidemic agent, S-2E, on blood lipid levels in rats with fructose-induced hypertriglyceridemia

Pharmacology. 2004 Dec;72(4):240-6. doi: 10.1159/000080379.

Abstract

Using rats with fructose-induced hypertriglyceridemia, an animal model of human hypertriglyceridemia, we investigated whether (+)-(S)-p-[1-(p-tert-butylphenyl)-2-oxo-4-pyrrolidinyl]-methoxybenzoic acid (S-2E), a novel anti-hyperlipidemic agent, reduced the elevated levels of triglyceride (TG) and non-high-density lipoprotein cholesterol (non-HDL-C), and then whether it elevated HDL-C levels. At doses of 3-30 mg/kg, S-2E reduced elevated TG levels and non-HDL-C levels simultaneously in a dose-dependent manner after a week. Furthermore, S-2E treatment at 10 mg/kg for 4 weeks showed similar effects, while the elongation of intervals between feeding periods led to further increases in these levels. Interestingly, S-2E increased blood HDL-C levels after 4 weeks of treatment. It is therefore reasonable to assume that S-2E may be useful to improve dyslipidemia such as hypertriglyceridemia and low levels of HDL-C.

MeSH terms

  • Animals
  • Benzoates / pharmacology*
  • Bezafibrate / pharmacology
  • Cholesterol / blood
  • Cholesterol, HDL / blood
  • Diet
  • Fructose*
  • Hydroxybenzoate Ethers
  • Hypertriglyceridemia / blood*
  • Hypertriglyceridemia / chemically induced
  • Hypolipidemic Agents / pharmacology*
  • Insulin Resistance
  • Lipid Metabolism
  • Lipids / blood*
  • Liver / drug effects
  • Liver / metabolism
  • Male
  • Pyrrolidinones / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Triglycerides / blood

Substances

  • 4-(1-(4-tert-butylphenyl)-2-oxo-4-pyrrolidinyl)methoxybenzoic acid
  • Benzoates
  • Cholesterol, HDL
  • Hydroxybenzoate Ethers
  • Hypolipidemic Agents
  • Lipids
  • Pyrrolidinones
  • Triglycerides
  • Fructose
  • Cholesterol
  • Bezafibrate