Synthesis of ring-oxidized retinoids as substrates of mouse class I alcohol dehydrogenase (ADH1)

Org Biomol Chem. 2004 Nov 21;2(22):3368-73. doi: 10.1039/B411585F. Epub 2004 Oct 11.

Abstract

Ring-oxidized retinoids have been synthesized stereoselectively using the Stille cross-coupling reaction. Kinetic constants of mouse class I alcohol dehydrogenase (ADH1) with these retinoids were determined.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohol Dehydrogenase / metabolism*
  • Animals
  • Biochemistry / methods*
  • Diterpenes
  • Kinetics
  • Mice
  • Oxidation-Reduction
  • Retinaldehyde / analogs & derivatives
  • Retinaldehyde / chemical synthesis
  • Retinaldehyde / chemistry
  • Retinaldehyde / metabolism
  • Retinoids / chemical synthesis*
  • Retinoids / chemistry
  • Retinoids / metabolism*
  • Structure-Activity Relationship
  • Substrate Specificity
  • Vitamin A / analogs & derivatives
  • Vitamin A / chemical synthesis
  • Vitamin A / chemistry
  • Vitamin A / metabolism

Substances

  • 4-hydroxy-retinol
  • Diterpenes
  • Retinoids
  • Vitamin A
  • 4-oxoretinaldehyde
  • Alcohol Dehydrogenase
  • Retinaldehyde