Linkage disequilibrium maps constructed with common SNPs are useful for first-pass disease association screens

Genomics. 2004 Dec;84(6):899-912. doi: 10.1016/j.ygeno.2004.08.009.

Abstract

To develop an efficient strategy for mapping genetic factors associated with common diseases, we constructed linkage disequilibrium (LD) maps of human chromosomes 5, 7, 17, and X. These maps consist of common single nucleotide polymorphisms at an average intermarker distance of 100 kb. The genotype data from these markers in a panel of American samples of European descent were analyzed to produce blocks of markers in strong pair-wise LD. Power calculations were used to guide block definitions and predicted that high-level LD maps would be useful in initial genome scans for susceptibility alleles in case-control association studies of complex diseases. As anticipated, LD blocks on the X chromosome were larger and covered more of the chromosome than those found on the autosomes.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Algorithms
  • Asian People / genetics
  • Black or African American / genetics
  • Case-Control Studies
  • Chromosome Mapping*
  • Chromosomes, Human, Pair 13 / genetics
  • Chromosomes, Human, X / genetics
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Genome, Human*
  • Genotype
  • Humans
  • Linkage Disequilibrium*
  • Polymorphism, Single Nucleotide*
  • White People / genetics