Highly diastereo- and enantioselective reagents for aldehyde crotylation

Org Lett. 2004 Nov 11;6(23):4375-7. doi: 10.1021/ol0480731.

Abstract

Two new, crystalline solid, storable, and highly enantioselective reagents for aldehyde crotylation have been developed. Both (cis and trans) crotylsilane reagents are easily prepared in bulk, require trivial reaction conditions, and provide the homoallylic alcohol products with near diastereo- and enantiospecificity in many cases.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aldehydes / chemistry*
  • Silanes / chemistry*

Substances

  • Aldehydes
  • Silanes
  • crotylsilane