Abstract
Strains of bifidobacteria have many health-promotion effects. Whole cells or cytoplasm extracts of Bifidobacterium bifidum BGN4, isolated from human feces, inhibited the growth of several cancer cell lines. The polysaccharide fraction (BB-pol) extracted from B. bifidum BGN4 had a novel composition, comprising chiroinositol, rhamnose, glucose, galactose, and ribose. Three human colon cancer cell lines were treated with BB-pol: HT-29, HCT-116, and Caco-2. Trypan blue exclusion assay and BrdU incorporation assay showed that BB-pol inhibited the growth of HT-29 and HCT-116 cells but did not inhibit the growth of Caco-2 cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Bifidobacterium / isolation & purification
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Bifidobacterium / metabolism*
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Bromodeoxyuridine / metabolism
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Cell Count
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Cell Line, Tumor
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Cell Proliferation / drug effects*
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Colonic Neoplasms
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Feces / microbiology
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Galactose / analysis
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Glucose / analysis
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Humans
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Inositol / analysis
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Polysaccharides, Bacterial / chemistry*
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Polysaccharides, Bacterial / isolation & purification
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Polysaccharides, Bacterial / pharmacology*
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Rhamnose / analysis
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Ribose / analysis
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Trypan Blue / metabolism
Substances
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Antineoplastic Agents
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Polysaccharides, Bacterial
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Inositol
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Ribose
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Bromodeoxyuridine
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Trypan Blue
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Glucose
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Rhamnose
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Galactose