Abstract
To determine reproducibility of inflammatory marker concentrations in induced sputum from subjects with cystic fibrosis (CF), 15 nonexpectorating children, 6 to 13 years of age with mild CF lung disease, underwent 3 weekly sputum inductions with 3% saline. Neutrophil elastase concentration and bacterial cultures were reproducible. This study provides useful information for investigators designing trials of anti-inflammatory therapies in CF involving sputum induction.
Publication types
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Clinical Trial
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Administration, Inhalation
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Adolescent
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Child
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Cystic Fibrosis / enzymology*
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Cystic Fibrosis / microbiology*
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Humans
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Interleukin-6 / metabolism
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Interleukin-8 / metabolism
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Leukocyte Elastase / metabolism
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Nebulizers and Vaporizers
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Peroxidase / metabolism
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Reproducibility of Results
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Sodium Chloride / administration & dosage
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Sputum / enzymology*
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Sputum / microbiology*
Substances
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Interleukin-6
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Interleukin-8
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Sodium Chloride
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Peroxidase
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Leukocyte Elastase