De novo complex chromosome rearrangement in identical twins with multiple congenital anomalies

Hum Genet. 1992 Mar;88(5):596-8. doi: 10.1007/BF00219353.

Abstract

A de novo and apparently balanced complex chromosome rearrangement (CCR) was found in monozygotic (MZ) twin infants with multiple congenital anomalies. The rearrangement involved 4 chromosomes with 6 breakpoints including 2p23, 2q13, 2q21.1, 3p23, 11q13.1, and 12q24.1. This seems to be the first report of a CCR in MZ twins. The relationship between this chromosome abnormality and MZ twinning is discussed.

Publication types

  • Case Reports

MeSH terms

  • Abnormalities, Multiple / genetics*
  • Adult
  • Chromosome Aberrations*
  • Chromosome Banding
  • Chromosome Disorders*
  • Chromosomes, Human, Pair 11
  • Chromosomes, Human, Pair 12
  • Chromosomes, Human, Pair 2
  • Chromosomes, Human, Pair 3
  • Diseases in Twins / genetics*
  • Female
  • Humans
  • Infant, Newborn
  • Karyotyping
  • Male
  • Translocation, Genetic*
  • Twins, Monozygotic / genetics*