Alternative splicing of interleukin-6 mRNA in mice

O P Yatsenko; M L Filipenko; E A Khrapov; E N Voronina; S V Sennikov; V A Kozlov

doi:10.1023/b:bebm.0000046944.85314.bf

Alternative splicing of interleukin-6 mRNA in mice

Bull Exp Biol Med. 2004 Jul;138(1):73-6. doi: 10.1023/b:bebm.0000046944.85314.bf.

Authors

O P Yatsenko¹, M L Filipenko, E A Khrapov, E N Voronina, S V Sennikov, V A Kozlov

Affiliation

¹ Laboratory for Regulation of Immunopoiesis, Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences.

PMID: 15514729
DOI: 10.1023/b:bebm.0000046944.85314.bf

Abstract

Expression of mRNA for interleukin-6, interleukin-6Delta3, and interleukin-6Delta5 was detected in placental tissue (second and third trimesters of pregnancy) and spleen of mice immunized with sheep erythrocytes in high dose. We hypothesize that translation of mRNA yields proteins capable of binding to individual subunits of the interleukin-6 receptor and possessing effector functions.

MeSH terms

Alternative Splicing*
Amino Acid Sequence
Animals
Binding Sites
Crosses, Genetic
Erythrocytes / immunology
Exons
Female
Interleukin-6 / chemistry
Interleukin-6 / genetics*
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Molecular Sequence Data
Placenta / metabolism
Pregnancy
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Protein Biosynthesis
Protein Isoforms / chemistry
Protein Structure, Secondary
RNA, Messenger / metabolism
Sequence Deletion
Sequence Homology, Amino Acid
Sheep
Spleen / metabolism

Substances

Interleukin-6
Protein Isoforms
RNA, Messenger