Abstract
Germline mutations in the BRCA1, BRCA2 and Fanconi anaemia genes confer cancer susceptibility, and the proteins encoded by these genes have distinct functions in related DNA-repair processes. Emerging evidence indicates that these processes are disrupted by numerous mechanisms in sporadic cancers. Collectively, there are properties that define 'BRCAness' - that is, traits that some sporadic cancers share with those occurring in either BRCA1- or BRCA2-mutation carriers. These common properties might have important implications for the clinical management of these cancers.
MeSH terms
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BRCA1 Protein / physiology
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BRCA2 Protein / physiology
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Breast Neoplasms / classification
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Breast Neoplasms / genetics*
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Breast Neoplasms / pathology
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DNA Damage
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DNA Repair / genetics*
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DNA, Neoplasm / genetics
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DNA, Neoplasm / metabolism
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Epigenesis, Genetic
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Fanconi Anemia / genetics
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Fanconi Anemia Complementation Group D2 Protein
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Fanconi Anemia Complementation Group F Protein
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Female
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Gene Expression Profiling
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Genes, BRCA1
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Genes, BRCA2
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Humans
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Nuclear Proteins / physiology
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Phenotype
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RNA-Binding Proteins / physiology
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Recombination, Genetic / genetics*
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Sequence Homology, Nucleic Acid
Substances
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BRCA1 Protein
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BRCA2 Protein
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DNA, Neoplasm
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FANCD2 protein, human
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FANCF protein, human
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Fanconi Anemia Complementation Group D2 Protein
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Fanconi Anemia Complementation Group F Protein
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Nuclear Proteins
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RNA-Binding Proteins