Stereoselective synthesis and antifungal activity of (Z)-trans-3-azolyl-2-methylchromanone oxime ethers

Saeed Emami; Mehraban Falahati; Ali Banifatemi; Abbas Shafiee

doi:10.1016/j.bmc.2004.08.030

Stereoselective synthesis and antifungal activity of (Z)-trans-3-azolyl-2-methylchromanone oxime ethers

Bioorg Med Chem. 2004 Nov 15;12(22):5881-9. doi: 10.1016/j.bmc.2004.08.030.

Authors

Saeed Emami¹, Mehraban Falahati, Ali Banifatemi, Abbas Shafiee

Affiliation

¹ Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, PO Box 48175-861 Sari, Iran.

PMID: 15498664
DOI: 10.1016/j.bmc.2004.08.030

Abstract

A series of (Z)-trans-3-azolyl-2-methylchromanone oxime ethers were stereoselectively synthesized and tested for in vitro antifungal activity. Many of these derivatives exhibit high activity against Candida albicans, Saccharomyces cerevisiae, Aspergillus niger, and Microsporum gypseum.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anthraquinones / chemical synthesis*
Anthraquinones / pharmacology
Antifungal Agents / chemical synthesis*
Antifungal Agents / pharmacology
Candida albicans / drug effects
Candida albicans / growth & development
Chromones
Microbial Sensitivity Tests / statistics & numerical data
Oximes / chemical synthesis*
Oximes / pharmacology
Stereoisomerism

Substances

Anthraquinones
Antifungal Agents
Chromones
Oximes
chaetomanone