Abstract
An efficient synthesis of (-)-9,10-epi-stemoamide has been accomplished in nine steps and 13% overall yield. The synthesis features a lithium hydroxide-promoted fragmentation and an intramolecular 7-exo-trig radical cyclization.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alkaloids / chemical synthesis*
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Catalysis
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Heterocyclic Compounds, 3-Ring / chemical synthesis*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plants, Medicinal / chemistry
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Stemonaceae / chemistry
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Stereoisomerism
Substances
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9,10-epi-stemoamide
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Alkaloids
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Heterocyclic Compounds, 3-Ring