Phosphorohydrazines of 4-oxo-4H-1-benzopyran and 1-benzopyran-2,4-dione exhibit antitumor activity against L1210 leukemia

Pharmazie. 2004 Sep;59(9):731-2.

Abstract

Phosphorohydrazines and phosphorohydrazones of benzopyran-2,4-dione as well as the phosphorohydrazone of 4-hydroxycoumarine were tested for antitumor activity in lymphatic leukemia L1210 bearing mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology*
  • Antineoplastic Agents / toxicity
  • Chromones / chemical synthesis*
  • Chromones / pharmacology*
  • Chromones / toxicity
  • Hydrazines / chemical synthesis*
  • Hydrazines / pharmacology*
  • Hydrazines / toxicity
  • Lethal Dose 50
  • Leukemia L1210 / drug therapy*
  • Leukemia L1210 / pathology
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred DBA
  • Neoplasm Transplantation
  • Organophosphorus Compounds / chemical synthesis*
  • Organophosphorus Compounds / pharmacology*
  • Organophosphorus Compounds / toxicity

Substances

  • Antineoplastic Agents
  • Chromones
  • Hydrazines
  • Organophosphorus Compounds