Abstract
LXRs are members of the nuclear receptor superfamily and function as master regulators of cholesterol metabolism. In the macrophage, they control cholesterol efflux and inhibit the transcription factor NF-kappaB-mediated proinflammatory responses. In this issue of Cell, discover surprising, protective functions for LXRalpha in innate immunity.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Comment
MeSH terms
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Animals
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Cholesterol / metabolism
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DNA-Binding Proteins
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Immunity, Innate*
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Listeria / immunology*
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Liver X Receptors
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Orphan Nuclear Receptors
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Protein Isoforms / metabolism
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Receptors, Cytoplasmic and Nuclear / immunology*
Substances
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DNA-Binding Proteins
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Liver X Receptors
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Orphan Nuclear Receptors
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Protein Isoforms
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Receptors, Cytoplasmic and Nuclear
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Cholesterol