Gamma interferon and interleukin 2, but not interleukin 4, are detectable in gamma/delta T-cell cultures after activation with bacteria

G A Follows; M E Munk; A J Gatrill; P Conradt; S H Kaufmann

doi:10.1128/iai.60.3.1229-1231.1992

Gamma interferon and interleukin 2, but not interleukin 4, are detectable in gamma/delta T-cell cultures after activation with bacteria

Infect Immun. 1992 Mar;60(3):1229-31. doi: 10.1128/iai.60.3.1229-1231.1992.

Authors

G A Follows¹, M E Munk, A J Gatrill, P Conradt, S H Kaufmann

Affiliation

¹ Department of Immunology, University of Ulm, Germany.

Abstract

Mycobacterium tuberculosis- or group A streptococcus-activated gamma/delta T cells from normal healthy individuals were negatively sorted and restimulated in vitro from 48 h. Significant amounts of gamma interferon were detected after restimulation with M. tuberculosis, group A streptococci, or Listeria monocytogenes. In contrast, interleukin 4 was undetectable in the culture supernatants. Our findings provide indirect evidence for the involvement of gamma/delta T cells in immunity against tubercle bacilli and probably other bacteria.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cells, Cultured
Humans
Interferon-gamma / biosynthesis*
Interleukin-2 / biosynthesis*
Interleukin-4 / biosynthesis*
Listeria monocytogenes / immunology
Lymphocyte Activation*
Mycobacterium tuberculosis / immunology*
Receptors, Antigen, T-Cell, gamma-delta / analysis*
Streptococcus pyogenes / immunology
T-Lymphocytes / immunology
T-Lymphocytes / metabolism*

Substances

Interleukin-2
Receptors, Antigen, T-Cell, gamma-delta
Interleukin-4
Interferon-gamma