Candidate regions of tumor suppressor gene by loss of heterozygosity analysis on chromosome 8p11.1-q13.3 in gastric cancer

Cancer Lett. 2004 Sep 15;213(1):111-6. doi: 10.1016/j.canlet.2004.03.041.

Abstract

Loss of heterozygosity (LOH) is an important event of tumorigenesis. In this paper, we report the comprehensive LOH analyses with microsatellite markers and their results at chromosome 8p11.1-q13.3 in gastric cancer. The microsatellite markers D8S2323 and D8S2330 exhibited high LOH frequencies, 54.2 and 57.1%, respectively. However, LOH at 8q showed no relationship to either histological types or stages of gastric cancer. Finally, we settled six candidate regions on 8q in gastric cancer where there was a high possibility of being the tumor suppressor gene(s), and concluded that the LOH of 8q occurred in the primary tumorigenesis of gastric cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosomes, Human, Pair 8*
  • Genes, Tumor Suppressor*
  • Humans
  • Loss of Heterozygosity*
  • Microsatellite Repeats
  • Polymerase Chain Reaction
  • Stomach Neoplasms / etiology
  • Stomach Neoplasms / genetics*