Monocyte chemoattractant protein-1 (MCP1) promoter -2518 polymorphism may confer a susceptibility to major depressive disorder in the Korean population

Psychiatry Res. 2004 Jul 15;127(3):279-81. doi: 10.1016/j.psychres.2004.04.004.

Abstract

We conducted a case-control association study of the monocyte chemoattractant protein-1 (MCP1) gene -2518 polymorphism in 90 patients with major depressive disorder. Genotyping was performed by polymerase chain reaction methods. We found significant differences in genotype and allele frequencies. The present study suggests that this polymorphism may confer a susceptibility to major depressive disorder in the Korean population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age of Onset
  • Case-Control Studies
  • Chemokine CCL2 / genetics*
  • DNA Primers / genetics
  • Depressive Disorder, Major / diagnosis
  • Depressive Disorder, Major / ethnology*
  • Depressive Disorder, Major / genetics*
  • Diagnostic and Statistical Manual of Mental Disorders
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Korea
  • Male
  • Polymerase Chain Reaction
  • Polymorphism, Genetic / genetics*

Substances

  • Chemokine CCL2
  • DNA Primers