Serum levels of 1,25-(OH)2-vitamin D are not altered by long-term supplementation with alphacalcidol (1-OH-vitamin D3). A double-blind, placebo-controlled study

Exp Clin Endocrinol. 1992;99(3):151-3. doi: 10.1055/s-0029-1211158.

Abstract

The endogenous production of 1,25-(OH)2-vitamin D has been estimated to be 1.5 micrograms daily. Despite the use of alphacalcidol (1,25-(OH)2-vitamin D) during more than a decade the long-term effects of the serum levels of 1,25-(OH)2-vitamin D have been poorly investigated. When 1 microgram of alphacalcidol was given daily to 39 non-vitamin D deficient subjects in a double-blind, placebo-controlled study during 4 months no significant effects on the serum levels of 1,25-(OH)2-vitamin D or 25-(OH)-vitamin D were found. The treatment however induced a 50% increase in urinary excretion of calcium (p less than 0.01). In conclusion, long-term supplementation with a physiological dose of alphacalcidol does not influence the serum levels of 1,25-(OH)2-vitamin D, despite a marked effect on urinary calcium excretion.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Calcitriol / blood*
  • Calcium / blood
  • Calcium / urine*
  • Double-Blind Method
  • Drug Administration Schedule
  • Female
  • Humans
  • Hydroxycholecalciferols / administration & dosage*
  • Male
  • Middle Aged
  • Parathyroid Hormone / blood

Substances

  • Hydroxycholecalciferols
  • Parathyroid Hormone
  • Calcitriol
  • Calcium
  • alfacalcidol