Large-scale analysis of pseudogenes in the human genome

ZhaoLei Zhang; Mark Gerstein

doi:10.1016/j.gde.2004.06.003

Large-scale analysis of pseudogenes in the human genome

Curr Opin Genet Dev. 2004 Aug;14(4):328-35. doi: 10.1016/j.gde.2004.06.003.

Authors

ZhaoLei Zhang¹, Mark Gerstein

Affiliation

¹ Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, Connecticut 06520-8114, USA.

PMID: 15261647
DOI: 10.1016/j.gde.2004.06.003

Abstract

Pseudogenes are considered as genomic fossils: disabled copies of functional genes that were once active in the ancient genome. Recently, whole-genome computational approaches have revealed thousands of pseudogenes in the genomes of the human and other eukaryotes. Identification of these pseudogenes can improve the accuracy of gene annotation. It also offers new insight on the evolutionary history and the stability of the genome as a whole.

Publication types

Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Amino Acid Sequence
Evolution, Molecular*
Gene Expression
Genome, Human*
Humans
Molecular Sequence Data
Pseudogenes / genetics*
Retroelements / genetics

Substances

Retroelements

Grants and funding

NP50 HG02357-01/HG/NHGRI NIH HHS/United States