Abstract
Stereoselective synthesis of squalamine dessulfates analogues, 7 alpha and 7 beta-N-[3N-(4-aminobutyl) aminopropyl]aminocholesterol are reported, using 7 alpha and 7 beta-aminocholesterol as a key intermediate. It's the first example in which the position of spermidine is modified at the steroid ring. These molecules showed a comparable antibacteria and fungi activities to squalamine. Then, they have a cytotoxic activity on a human non-small cell bronchopulmonary carcinoma line (NSCLC-N6).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Antifungal Agents / chemical synthesis
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology
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Bronchial Neoplasms / pathology
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Carcinoma, Non-Small-Cell Lung / pathology
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Cell Line, Tumor
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Cholestanols / chemical synthesis*
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Cholestanols / chemistry
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Cholestanols / pharmacology
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Drug Screening Assays, Antitumor
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Humans
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Lung Neoplasms / pathology
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Cholestanols
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squalamine