Replication factors license exonuclease I in mismatch repair

Mol Cell. 2004 Jul 23;15(2):164-6. doi: 10.1016/j.molcel.2004.07.004.

Abstract

A key question in the eukaryotic mismatch repair field is how strand excision is coordinated with mismatch recognition. In a recent issue of Molecular Cell, Dzantiev et al. present evidence that the replication factors PCNA and RFC modulate the directionality of EXOI-mediated excision.

Publication types

  • Editorial
  • Comment

MeSH terms

  • Animals
  • Base Pair Mismatch / genetics*
  • Chromatin / metabolism*
  • DNA / genetics
  • DNA Repair / genetics*
  • DNA Repair Enzymes
  • DNA Replication*
  • DNA-Binding Proteins / metabolism
  • Exodeoxyribonucleases / metabolism*
  • Humans
  • Proliferating Cell Nuclear Antigen / metabolism
  • Replication Protein C
  • Transcription Factors / metabolism

Substances

  • Chromatin
  • DNA-Binding Proteins
  • Proliferating Cell Nuclear Antigen
  • RFC1 protein, human
  • Transcription Factors
  • DNA
  • EXO1 protein, human
  • Exodeoxyribonucleases
  • exodeoxyribonuclease I
  • Replication Protein C
  • DNA Repair Enzymes