Systemic mastocytosis associated with acute myeloid leukemia: case report and implications for disease pathogenesis

J Allergy Clin Immunol. 2004 Jul;114(1):28-33. doi: 10.1016/j.jaci.2004.02.042.

Abstract

Mastocytosis may be associated with clonal nonmast cell lineage hematologic diseases, including myelodysplastic syndromes, myeloproliferative disorders, and acute myeloid leukemia. Here we present a patient with the simultaneous diagnosis of mastocytosis and an acute myeloid leukemia, M2 subtype in the French-American-British classification, with t(8;21) carrying a population of immature mast cell precursors, and discuss this presentation in the context of a potential pathogenetic cellular link between this leukemia and mastocytosis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Female
  • Humans
  • Leukemia, Myeloid, Acute / complications*
  • Leukemia, Myeloid, Acute / diagnosis
  • Leukemia, Myeloid, Acute / immunology*
  • Leukemia, Myeloid, Acute / therapy
  • Mastocytosis, Systemic / complications*
  • Mastocytosis, Systemic / diagnosis
  • Mastocytosis, Systemic / immunology*
  • Mastocytosis, Systemic / therapy