5-Exo-dig radical cyclization of enediynes: the first synthesis of tin-substituted benzofulvenes

Org Lett. 2004 Jul 8;6(14):2457-60. doi: 10.1021/ol049122c.

Abstract

[reaction: see text] Bu(3)Sn-mediated 5-exo-dig radical cyclization of diaryl enediynes provides a mild and efficient approach to tin-substituted fulvenes. Further synthetic opportunities opened by this process and general factors responsible for the observed regio- and stereoselectivity are outlined.