A randomized comparison of oral chloroquine and sulfadoxine-pyrimethamine for the treatment of uncomplicated Plasmodium falciparum malaria in Laos

Trans R Soc Trop Med Hyg. 2003 May-Jun;97(3):343-4. doi: 10.1016/s0035-9203(03)90165-9.

Abstract

Between June and October 2000 we conducted the first randomized trial in Laos comparing chloroquine (CQ) with sulfadoxine-pyrimethamine (SP) in the treatment of uncomplicated Plasmodium falciparum malaria (n = 29, 42-d follow-up, age > 5 years). The proportion of patients with treatment failure was high (CQ = 78%, RIII 46%; SP = 36%, RIII 15%). The treatment policy for uncomplicated P. falciparum malaria in Laos needs to be reviewed urgently.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Adolescent
  • Antimalarials / therapeutic use*
  • Child
  • Chloroquine / therapeutic use*
  • Drug Combinations
  • Humans
  • Malaria, Falciparum / drug therapy*
  • Pyrimethamine / therapeutic use*
  • Single-Blind Method
  • Sulfadoxine / therapeutic use*
  • Treatment Failure

Substances

  • Antimalarials
  • Drug Combinations
  • fanasil, pyrimethamine drug combination
  • Sulfadoxine
  • Chloroquine
  • Pyrimethamine